|Title:||Barretts Oesophagus Screening Trial
|Principal research question:||Is the Cytosponge test an accurate and well-tolerated method to diagnose Barrett’s oesophagus in primary care?
|Methodology & sample group:||Eligible participants, aged 50 - 70 years old, who have taken medication for acid indigestion or heartburn for more than 3 months in the last 5 years as identified from the GP prescribing database. Only patients registered with specific participating GP practices are invited to take part.
The Cytosponge is an ingestible gelatine capsule containing a compressed mesh attached to a string. After swallowing, the capsule dissolves in the proximal stomach to release the mesh, which is withdrawn after 5 minutes by pulling on the string. The cytological specimens are immediately placed into preservative fluid and transported to the laboratory for processing.
|Outcome measure:||1. Sensitivity and specificity of the test for detecting Barrett’s oesophagus with gastroscopy as gold standard;
2. Acceptability to participants (questionnaire using validated measures).
|Start date:||1st April 2007|
|End date:||31st March 2010|
|Contact person in the Unit:||Dr Helen Morris
General Practice & Primary Care Research Unit
Institute of Public Health
University Forvie Site
Telephone: (01223) 330592
Fax: 01223 762515
|Unit team collaborators:||Jon Emery, Helen Morris, Fiona Walter|
|Project leaders:||Dr Rebecca Fitzgerald and Dr Sunny Kadri at the MRC Cancer Cell Unit, Cambridge|
|Collaborators:||Pierre Lao-Sirieix, Maria O’Donovan, Irene Debiram, Madhumita Das, Alex Boussioutas, Jane Blazeby, Paul Pharoah, Richard Hardwick
|Funding Organisation:||Medical Research Council|
|Funding Organisation:||NIHR School for Primary Care Research|