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Home > Research > Research Projects List > BEST: Barretts Oesophagus Screening Trial

BEST: Barretts Oesophagus Screening Trial

Title: Barretts Oesophagus Screening Trial
Principal research question: Is the Cytosponge test an accurate and well-tolerated method to diagnose Barrett’s oesophagus in primary care?
Methodology & sample group: Eligible participants, aged 50 - 70 years old, who have taken medication for acid indigestion or heartburn for more than 3 months in the last 5 years as identified from the GP prescribing database. Only patients registered with specific participating GP practices are invited to take part.

The Cytosponge is an ingestible gelatine capsule containing a compressed mesh attached to a string. After swallowing, the capsule dissolves in the proximal stomach to release the mesh, which is withdrawn after 5 minutes by pulling on the string. The cytological specimens are immediately placed into preservative fluid and transported to the laboratory for processing.
Outcome measure: 1. Sensitivity and specificity of the test for detecting Barrett’s oesophagus with gastroscopy as gold standard;

2. Acceptability to participants (questionnaire using validated measures).
Project organisation
Start date: 1st April 2007
End date: 31st March 2010
Contact person in the Unit: Dr Helen Morris
General Practice & Primary Care Research Unit
Institute of Public Health
University Forvie Site
Robinson Way
Telephone: (01223) 330592
Fax: 01223 762515
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Unit team collaborators: Jon Emery, Helen Morris, Fiona Walter
Project leaders: Dr Rebecca Fitzgerald and Dr Sunny Kadri at the MRC Cancer Cell Unit, Cambridge
Collaborators: Pierre Lao-Sirieix, Maria O’Donovan, Irene Debiram, Madhumita Das, Alex Boussioutas, Jane Blazeby, Paul Pharoah, Richard Hardwick
Funding information
Funding Organisation: Medical Research Council

Funding Organisation: NIHR School for Primary Care Research

Last Updated on Tuesday, 30 March 2010 13:47