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Department of Paediatrics |
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| School of Clinical Medicine > Department of Paediatrics > Research |
Dr Carlo Acerini
Biography I qualified in Pharmacology
(BSc Hons -
1984) and in Medicine (MBChB - 1988) from the University of the West of Scotland, I
specialized in
paediatric endocrinology & diabetes as a clinical research
fellow
and then as clinical lecturer at the Universities of I am currently a University
Senior
Lecturer and a Honorary Consultant Paediatrician (Endocrinology
& Diabetes) at Addenbrooke's Hospital, Cambridge (appointed
2000). Research I am active in clinical
research in the areas of paediatric and adolescent diabetes and
endocrinology. My
main area
of diabetes related research include studies into the pathophysiology
of
insulin resistance in children and adolescents with Type 1 and the
development
of novel therapeutic approaches to improve glycaemic control in
patients with
diabetes. My
paediatric endocrine research includes studies related to
neuroendocrine
consequences of acquired brain injury, including the epidemiology and
natural
history of traumatic brain injury induced hypothalamic-pituitary
dysfunction. I
am also
one of the principle investigators co-ordinating the Cambridge Baby
Growth
Study (est. 2001), which is a prospective, longitudinal study designed
to
assess the impact of genetic factors and the role of the maternal
in-utero
environment (including exposure to endocrine disrupting chemicals) on
pre /
postnatal growth and reproductive health. I
also have
a interest in the area of applied GH therapy research Other
research roles: Associate Director of the
Addenbrooke’s
Clinical Research Centre Clinical Lead for the UK
Medicines for
Children Research Network for the West Anglia CLRN area. Teaching I am Attachment Director
for the MB
Stage 2 (Clinical) Growth and Development (Paediatrics) course. I am a Bye Fellow at Girton
College,
Cambridge, and supervise undergraduate students in Human Reproduction
(MVST
part 1B) course. Clinical I am clinical lead for the
Paediatric
& Adolescent Diabetes and Endocrinology service based at the Weston
Centre,
Institute of Metabolic Science at Addenbrooke’s Hospital. I am also the chair (2009 -
) of the
East of England Paediatric Diabetes Network. Other
activities Author and co-editor of the
Oxford
Handbook of Paediatrics (OUP) Associate Editor for the
journals Diabetic Medicine and Frontiers
in Paediatric Endocrinology Publications Publications
as listed in Pubmed by the
U.S. National Library of Medicine. Recent
publications: 1.
Beardsall K,
Pesterfield CL, Acerini CL. Neonatal
diabetes and insulin pump therapy. Arch Dis Child Fetal Neonatal Ed.
2010 Dec 7
[Pub ahead of print] 2.
Elleri D,
Allen JM, Nodale M, Wilinska ME, Acerini
CL, Dunger DB, Hovorka R. Suspended insulin infusion during
overnight
closed-loop glucose control in children and adolescents with Type 1
diabetes.
Diabet Med. 2010 Apr;27(4):480-4. 3.
Lek N,
Prentice P, Williams RM, Ong KK, Burke GA, Acerini
CL. Risk factors for obesity in childhood survivors of suprasellar
brain tumours:
a retrospective study. Acta Paediatr.
2010 May 17. 4.
Regan FM,
Williams RM, McDonald A, Umpleby AM, Acerini
CL, O'Rahilly S, Hovorka R, Semple RK, Dunger DB. Treatment with
Recombinant Human Insulin-Like Growth Factor (rhIGF)-I/rhIGF Binding
Protein-3
Complex Improves Metabolic Control in Subjects with Severe Insulin
Resistance. J Clin Endocrinol Metab.
2010 Mar 16. 5.
Wilinska ME,
Chassin LJ, Acerini CL, Allen JM,
Dunger DB, Hovorka R. Simulation
environment to evaluate closed-loop insulin delivery systems in type 1
diabetes. J Diabetes Sci Technol. 2010 Jan 1;4(1):132-44. 6.
Hovorka R,
Allen JM, Elleri D, Chassin LJ, Harris J, Xing D, Kollman C, Hovorka T,
Larsen
AM, Nodale M, De Palma A, Wilinska ME, Acerini
CL, Dunger DB. Manual closed-loop insulin delivery in children and
adolescents with type 1 diabetes: a phase 2 randomised crossover trial.
Lancet.
2010 Feb 4. [Epub ahead of print] 7.
Wei C, Lunn
DJ, Acerini CL, Allen JM, Larsen AM,
Wilinska ME, Dunger DB, Hovorka R. Measurement delay associated with
the
Guardian RT continuous glucose monitoring system. Diabet Med. 2010
Jan;27(1):117-22. 8.
Elleri D, Acerini CL,
Allen JM, Hayes J,
Pesterfield C, Wilinska ME, Dunger DB, Hovorka R. Parental attitudes
towards
overnight closed-loop glucose control in children with type 1 diabetes. Diabetes Technol Ther. 2010 Jan;12(1):35-9. 9.
Balasubramanian
M, Shield JP, Acerini CL, Walker J,
Ellard S, Marchand M, Polak M, Vaxillaire M, Crolla JA, Bunyan DJ,
Mackay DJ,
Temple IK. Pancreatic hypoplasia presenting with neonatal diabetes
mellitus in
association with congenital heart defect and developmental delay. Am J
Med
Genet A. 2010 Feb;152A(2):340-6. 10.
Thankamony A,
Ong KK, Dunger DB, Acerini CL,
Hughes IA. Anogenital distance from
birth to 2 years: a population study. Environ
Health Perspect. 2009 Nov;117(11):1786-90. Other links Addenbrookes Clinical
Research Centre Weston Centre,
Institute of Metabolic Science, Cambridge East of England Paediatric Diabetes
Network Contact information Department of
Paediatrics Level 8 / Box 116 Addenbrooke’s
Hospital Cambridge CB2 0QQ Direct: Tel: 01223 336865 Secretary: Mrs Dianne Gunton Tel: 01223 768618 |
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