Professor David Dunger
Our research group has a major interest in diabetes
research; in particular in the early detection and prevention of
diabetic complications and the effects of hormonal changes on glycaemic
control and
growth during puberty. For many years we have been following a cohort
of 500 children recruited at diagnosis to look for early markers of
later diabetic complications and this study is soon to be expanded
with the recruitment of another 1,000 children. Through collaboration
with Professor John Todd's group we will also be looking at the
putative genetic determinants of risk of diabetic complications. The
growth and endocrine changes during puberty in normal children and
those with chronic diseases such as diabetes and cystic fibrosis is an
on-going interest of the group.
In collaboration
with Professor Jean Golding and the Avon
Longitudinal Study of Parents and Children, we have been
examining the endocrine and genetic determinants of size at birth and
early childhood growth. These studies will be continuing over the next
5 years, by which time the ALSPAC cohort will have reached puberty. In
addition to our interest in the biological regulation of growth, we
will explore possible links between size at birth, early growth and
adult diseases such as type 2 diabetes and insulin resistance.
Publications
as listed in Pubmed
by the U.S. National Library
of Medicine.
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