Professor Ieuan Hughes

Professor Hughes has an interest in normal and abnormal sex differentiation in humans. His studies involve hormonal control of gene transcription by androgens in relation to XY sex reversal syndromes. The Cambridge Intersex Database now has clinical, biochemical, histological and molecular information on more than 1500 intersex cases referred for diagnostic investigations. The database is focussed on syndromes of androgen insensitivity (complete and partial) but also has information relating to androgen biosynthetic defects, gonadal dysgenesis, true hermaphroditism and specific eponymous syndromes. Studies on hypospadias, the commonest congenital malformation in males, are also undertaken. These include epidemiological, biochemical and genetic studies on the putative role of endocrine disruptors on male reproductive disorders. Clinical research is undertaken on congenital adrenal hyperplasia and a range of endocrine disorders of childhood.

Professor Hughes is currently Chair of the Committee on Toxicity of Chemicals in Food, Consumer Products and the Environment.

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