Internationally renowned academic and clinical immunologist who studied autoimmunity and inflammation and clinical and translational immunology The Clinical School is sad to note the death of Professor Sir Peter Lachmann FRS FMedSci on Saturday 26th December 2020. Professor Lachman made a major contribution, not only to scholarship in Cambridge, but also to the Clinical School, […]
Stroke in COVID-19: a systematic review and meta-analysis
A study by Stefania Nannoni (Clinical Neurosciences) aimed to clarify the relationship between COVID-19 and acute cerebrovascular diseases (CVD), through a systematic review and meta-analysis. The team, led by Hugh Markus (Clinical Neurosciences), characterised the incidence, risk factors, clinical-radiological manifestations and outcome of COVID-19-associated stroke. Accepted for publication in The International Journal of Stroke, the researchers reviewed articles on acute CVD in […]
DNA signals identify those at greatest risk of oesophageal cancer
A study, co-led by Rebecca Fitzgerald (MRC Cancer Unit and CRUK Cambridge Centre Early Detection Programme), has developed a statistical model that uses genomic data to predict the risk of developing cancer of the oesophagus up to eight years before diagnosis. Published in Nature Medicine, the researchers analysed DNA from tissue biopsies taken from patients […]
How Dantu blood group protects against malaria – and how all humans could benefit
A study, led by Julian Rayner and Michael Weekes (both Cambridge Institute for Medical Research), in collaboration with scientists at the Wellcome Sanger Institute, the Cavendish Laboratory and the KEMRI-Wellcome Trust Research Programme in Kenya, has identified how the Dantu genetic blood variant helps to protect against malaria. Malaria remains a major global health problem […]
Integrated Cancer Medicine trial opens
The DIRECT study is a molecular profiling study for patients with diffuse large B cell lymphoma (DLBCL) and closely related aggressive lymphomas. DLBCL is the commonest haematological malignancy with over 4,500 cases annually in the UK. Patients with DLBCL will be recruited from Addenbrooke’s Hospital and four other UK teaching hospitals. The Cancer Molecular Diagnostics […]
“NOW” – Two worlds one goal
NOW – a Crowdfunding campaign to connect scientific research to the world of patients by supporting four cancer patients’ associations. Scientific research is essential for the well-being of society, but quite often it takes many years to collect the results from our research with no immediate effect on the patients. The timing of research and […]
Single cell RNA-sequencing reveals a dynamic stromal niche that supports tumour growth
Cancer cells are surrounded by a diverse range of “normal cells” known as the stroma. The stroma includes immune cells, endothelial cells, fibroblasts and the extracellular matrix scaffold they produce. Together cancer cells and stroma form the tumour microenvironment. Crosstalk between the tumour and stroma is critical to help a tumour form and grow, but […]
Analysis of NHS health records of 3.8 million adults yields estimate of COVID-19 mortality according to underlying conditions and age
An analysis by Claudia Langenberg (MRC Epidemiology Unit) and collaborators from UCL, University College London Hospitals NHS Foundation Trust, and Health Data Research UK, indicates that at least 20% of the UK population has a high-risk underlying condition for COVID-19 infection listed by Public Health England. The authors have created a publicly accessible COVID-19 risk calculator showing how […]
150 scientists from new institute join Cambridge fight against COVID-19
One of Cambridge’s newest institutes, established to study the relationship between infectious disease and our immune systems, is leading the University of Cambridge’s response to the COVID-19 pandemic, with over 150 scientists and clinicians, the UK’s largest academic Containment Level 3 Facility, and a range of collaborators from across the UK and beyond.
Opinion: Does the amount of COVID-19 someone is exposed to determine how sick they will get?
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