A paper in Nature Communications by Iva Filipovic in Dr Francesco Colucci’s group, Department of Obstetrics and Gynaecology, uses mouse models to understand uterine lymphocytes. The uterus of humans and mice is home to many immune cells, including natural killer (NK) and other innate lymphoid cells (ILCs), which may play important roles in pregnancy. The […]

A recent paper by Christian Gawden-Bone from Professor Gillian Griffiths’ laboratory, CIMR, and published in Immunity, has identified the mechanism by which receptor-mediated recognition triggers localised changes in membrane composition to establish a zone for granule secretion. Cytotoxic T lymphocytes are key cells in the immune system, able to recognise and destroy both virally infected and […]

In Nature Communications, Alexandra Davies from Professor Margaret Robinson’s lab, CIMR, has uncovered a novel role for the adaptor protein AP-4 in regulating the cellular recycling process autophagy. AP-4 belongs to a family of proteins that select cargo for vesicle transport between specific organelles. Although mutations in AP-4 have been linked to a severe recessive […]

Dr Luca Lotta, MRC Epidemiology Unit, has led research that has identified the possibility of pairing new drugs with statins to reduce the risk of heart disease and diabetes. The study, published in published in Jama Cardiology, examines new drugs that lower levels of triglycerides (a type of fat) in blood and concludes that they could […]

A study, by Professor Lalita Ramakrishnan and Professor Paul Edelstein, Department of Medicine, in collaboration with Marcel Behr published in the British Medical Journal, analysed multiple longitudinal epidemiological studies to show that the majority of TB disease manifests soon after infection, with disease rarely occurring more than two years after infection. “If you skin test people […]

Research led by Dr Anita Chandra, Department of Medicine, has identified a novel population of B regulatory cells in a mouse model of the human immunodeficiency, Activated PI3Kinase δ syndrome (APDS). In an article published in Nature Communications, the researchers have shown that in a similar way to human patients, mice with APDS are susceptible […]

Dr Ben Hall, MRC Cancer Unit, and his research group have begun exploring how membrane transporters can be used as potential markers or drug targets in the future. Published in Nature Communications, their research shows for the first time that alterations in the expression of these membrane transporters consistently occur in all cancers. Membrane transporters […]

Dr Mark Evans, Department of Medicine and Institute of Metabolic Science, collaborated with researchers in Exeter to study how the specialised hexokinase, glucokinase, works in glucose-sensing cells in body to detect hypoglycemia (low blood glucose). Reporting in Molecular Metabolism, they found that mice and humans with molecular reductions in glucokinase action have increased counter-regulatory hormone […]