Collaborative research, led by Florian Merkle (Wellcome-MRC Institute of Metabolic Science), has analysed the genetics of human pluripotent stem cells (hPSCs) at single nucleotide resolution, revealing a wealth of biological insights and identifying cell lines particularly suitable for diverse applications. HPSCs are remarkable since they can self-renew indefinitely while retaining the ability to differentiate into […]
The Carbon Footprint of Bioinformatics
A study by Jason Grealey (Cambridge Baker Systems Initiative, Melbourne) and Loïc Lannelongue (Public Health and Primary Care, Cambridge Baker Systems Initiative), led by Michael Inouye (Public Health and Primary Care, Cambridge Baker Systems Initiative), has quantified the carbon footprint of widely used algorithms in bioinformatics, computational biology and statistical genetics. The study raises awareness, […]
Genetic mutations causing a type of adult blood cancer occur in childhood, or even in the womb
A collaborative study from the Wellcome Sanger Institute (WSI) and the University of Cambridge, led by Jyoti Nangalia (Haematology, Cambridge Stem Cell Institute (CSCI) and WSI), Peter Campbell (WSI) and Tony Green (Haematology and CSCI) has traced genetic mutations, linked to adult blood cancer, to childhood, showing that they proliferate in the body over decades […]
Magnesium is essential for the immune system, including in the fight against cancer
Researchers, including Adrià-Arnau Martí i Líndez and led by Christoph Hess (both Medicine, CITIID), have shown that the level of extracellular magnesium is an important factor in the immune system’s ability to tackle pathogens and cancer cells. The collaborative project, with the University of Basel, reported that T cells need a sufficient quantity of magnesium […]
Use of whole genome sequencing to determine the genetic basis of suspected mitochondrial disorders
A collaborative study by Katherine Schon, led by Patrick Chinnery (both Clinical Neurosciences and MRC Mitochondrial Biology Unit), demonstrates that whole genome sequencing (WGS), from a single blood test, picks up 31% more cases of rare genetic disorders than standard tests, shortening the ‘diagnostic odyssey’ that affected families experience, and providing huge opportunities for future […]
How HUSH defends your genome from DNA invasion
Research by Marta Seczynska, led by Paul Lehner (both Medicine, CITIID) in collaboration with Sergio Martinez Cuesta (Discovery Sciences, AstraZeneca) shows how the HUSH complex protects the human genome from foreign (retroelement) invasion. The human genome is under constant threat from invasion by mobile genetic elements. These include viruses (such as HIV) and retrotransposons (Line […]
Rhodri Wilson Memorial Fund 2022
The Fund Managers will award grants towards medical elective travel in 2022. Individual awards will be influenced by other grants and, in any case, are unlikely to exceed £250 each. Clinical medical students from any Cambridge College are eligible to apply. Applications for the support of electives in developing countries are particularly welcome. The application […]
Climate emergency declaration
The University of Cambridge School of Clinical Medicine is joining many other healthcare organisations (Health Declares) in declaring that the global climate and ecological emergency is a major crisis for health and healthcare. We agree with recent statements from the WHO and in The Lancet that climate change is an urgent global health threat. Extreme […]
Clinical School Annual Distinguished Lecture 2021
Clinical School Annual Distinguished Lecture Recorded: 23 September 2021 Speaker: Wendy Bickmore, Director of the MRC Human Genetics Unit, Institute of Genetics and Cancer at the University of Edinburgh. Talk Title: “Function and dysfunction in the non-coding genome” Professor Bickmore’s talk focused on non-coding genetic elements called “enhancers”, how they regulate our genes often over […]
New risk calculator to help save many more lives from heart attack and stroke
A new risk calculator will better predict people at high risk of heart and circulatory diseases years before they strike, and is ready for use across the UK and Europe, according to research published today in the journal European Heart Journal. This risk tool… will fit seamlessly into current prevention programmes with substantial real-world […]
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