Research by Claudia Langenberg and Nick Wareham (MRC Epidemiology Unit), as part of the Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders of Later Life programme, reported that proteins in our blood could help provide a comprehensive ‘liquid health check’, assessing our health and predicting the likelihood that we will we will develop a […]
Lack of evidence of neoantigen depletion in cancer genomics data
Research from Martin Miller (CRUK Cambridge Institute) and colleagues has identified that there is a lack of detectable neoantigen depletion signals in the untreated cancer genome using current state-of-the-art major histocompatibility complex (MHC) class I prediction tools. Published in Nature Genetics they show that negative selection of “immunogenic” mutations are not as apparent as previously […]
Recurrently mutated genes in benign skin tumours and a phenomenon of benign metastases
Helen Davies, from the Nik-Zainal group (both MRC Cancer Unit and Medical Genetics), has studied tumours derived from patients with a hereditary condition called CYLD cutaneous syndrome (CCS), in collaboration with Neil Rajan (Newcastle University). Patients with CCS develop multiple skin tumors over the scalp, face and body, called cylindromas and spiradenomas. While they are […]
Childhood Obesity linked to structural brain differences
A study by Lisa Ronan (Psychiatry) and Paul Fletcher (Psychiatry) has uncovered distinct differences in brain structure in obese children compared to those of normal weight. Published in Cerebral Cortex, the study aimed to determine whether differences in brain structure mediate the relationship between executive function and childhood obesity. The researchers analysed MR-derived measures of cortical thickness […]
The use of antidepressants by over 65s has a substantial increase in 20 years
A study led by Carol Brayne (Public Health and Primary Care) has shown that the number of people over 65 taking antidepressants has more than doubled in 20 years. Depression is a leading cause of disability, with older people particularly susceptible to poor outcomes. Published in The British Journal of Psychiatry, researchers investigated whether the prevalence […]
Switching to dry powder inhalers could reduce carbon emissions and cut costs
Work by year 6 student Rory Braggins modelling the financial and environmental impacts of switching to more environmentally sustainable inhalers has been just been published in BMJ Open. Working with Alex Wilkinson, (British Thoracic Society) and James Smith, (Public Health and Primary Care), Rory’s work demonstrated that large scale switching to dry powder inhalers could be done […]
Website launched with plans for Cambridge Children’s hospital and research institute
Plans for a ground-breaking new children’s hospital and research institute on the Cambridge Biomedical Campus moved a step closer last week, with the launch of a new website. Researchers from multiple departments at the School of Clinical Medicine, led by Paediatrics and Psychiatry, are working with Cambridge University Hospitals (CUH) and the Cambridgeshire and Peterborough […]
A small reduction in alcohol can significantly reduce heart disease risk in type 2 diabetes patients
New research undertaken by Jean Strelitz (MRC Epidemiology Unit) and colleagues at the Unit’s Prevention of Diabetes and Related Metabolic Disorders in High Risk Groups programme indicates that reducing alcohol use by as little as two units per week may have long-term health benefits for people with diabetes. Published in Cardiovascular Diabetology, the ADDITION […]
Moderate exercise in obese pregnancy restores key tissues
Research from joint first author Denise Fernandez-Twinn (Institute of Metabolic Science (IMS)) shows that exercise immediately prior to and during pregnancy restores key tissues in the body, making obese mice better able to manage blood sugar levels and lowering the risk of long-term health problems. The research, published in Physiological Reports, was carried out in […]
Case study: boosting the involvement of medical students in research at Cambridge
A new and innovative Medical Student Systematic Reviews Group, at the University of Cambridge School of Clinical Medicine, enabled 53 medical students to contribute directly to ongoing systematic reviews in 16 different research groups during 2018/9. The Group is launching for its second year this week and more details are available here. Systematic reviews are […]
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