In a paper published in Cell, Agatha van der Klaauw from Sadaf Farooqi’s team (Wellcome-MRC Institute of Metabolic Science) describes the role of a group of neural guidance molecules, the Semaphorins in the development of hypothalamic brain circuits that regulate body weight. The team characterised rare genetic variants affecting the function of multiple genes encoding the […]
Gene variations that reduce ability to store fat around the hips linked to higher risk of diabetes and heart attacks
A new genetic study of over 600,000 people, led by Claudia Langenberg and Luca Lotta (MRC Epidemiology Unit) indicates that people who are less likely to put on excess fat around their hips are at higher risk of type 2 diabetes and heart attacks. The new research, published in JAMA, sheds light on the specific […]
Positive patient feedback from partial breast radiotherapy
Charlotte Coles (Oncology and Cambridge Cancer Centre) and researchers at The Institute of Cancer Research (ICR), London, have published the five-year follow up of patient reported outcomes from the IMPORT LOW trial in the Journal of Clinical Oncology. The trial, which recruited over 2,000 women aged 50 or over, who had breast conserving surgery for invasive ductal adenocarcinoma, […]
Clinical Development of Novel Drug-Radiotherapy Combinations
An article by Saif Ahmad (MRC Cancer Unit) recently published in Clinical Cancer Research, focused on improving the number of effective drug-radiotherapy combinations entering the clinic. Richard Baird, Academic Consultant in Breast Cancer Therapeutics, was a co-author on this article and is leading the CamBMT1 trial which is a multi-centre early phase study examining the role of combining drugs […]
When are transfusions of platelets indicated for preterm babies?
Dr Anna Curley, Department of Paediatrics, has led the PlaNeT-2 study which explores the proper threshold for preventative platelet transfusions in preterm babies, who can become thrombocytopenic and subject to major bleeding disorders such as intra-ventricular haemorrhage. The study, published in The New England Medical Journal, was designed to compare outcomes for preterm babies […]
How hospital doctors can improve public health
Dr James McGowan, THIS Institute, and collaborators from West Suffolk NHS Foundation Trust and the University of Michigan, have demonstrated that hospital-based doctors can make important contributions to improving population health through the application of public health principles to clinical practice in hospitals. In a study, published in the British Journal of Hospital Medicine, the […]
Viral RNA causes inflammation by binding more efficiently to MDA5 during ATP hydrolysis
A study by Qin Yu and Kun Qu, led by Yorgo Modis, Molecular Immunity Unit, Department of Medicine, yields insights on how the innate immune system recognises viral genetic material during infection, and how this material is distinguished from chemically similar components inside the host cell. Published in Molecular Cell, the authors examined how the innate immune sensor […]
2018 Oon Lecture: Medicine 2.0 with Professor van der Schaar
2018 Oon Lecture Medicine 2.0: Transforming Clinical Practice and Discovery through Machine Learning and Electronic Health Engines Professor Mihaela van der Schaar This lecture was held on Tuesday 20 November 2018 in the Howard Theatre, Downing College. Read more about the event and watch a recording of the lecture here
Shedding light on uterine lymphocytes: the power of mouse models
A paper in Nature Communications by Iva Filipovic in Dr Francesco Colucci’s group, Department of Obstetrics and Gynaecology, uses mouse models to understand uterine lymphocytes. The uterus of humans and mice is home to many immune cells, including natural killer (NK) and other innate lymphoid cells (ILCs), which may play important roles in pregnancy. The […]
Genomic risk score test to predict coronary heart disease
A recent study, led by Dr Mike Inouye and Dr Gad Abraham, Department of Public Health and Primary Care, that used data from 500,000 participants, describes the development and evaluation of a novel genomic score that substantially advances the concept of using genomic information to stratify individuals with different trajectories of coronary artery disease (CAD) risk. […]
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