Dr Melissa Gammons

Project/study information 

Cells communicate by signal transduction pathways whereby secreted molecules bind to receptors on target cells to trigger intracellular responses. Misregulation of these pathways is a leading cause of rare genetic diseases, neurological disorders and cancer. Our focus is on Wnt signalling, a collection of pathways regulating an array of cellular processes including cell proliferation, differentiation, migration and polarity.

We investigate how Wnts are able to selectively regulate either morphogenetic processes, namely migration and polarity, or cell fate decisions, such as proliferation.

We also investigate how misregulation of Wnt signalling, by abnormal expression and/or mutations cause rare genetic diseases, such as the skeletal dysplasia Robinow Syndrome and related disorders.

By better understanding how these pathways work at the molecular level, scientists will be able to devise better more targeted therapies.

Recruitment of PhD / Post doctoral students

We have various projects that can be tailored to individual interests and background. Please email for more information