Oscar Rueda

Professor Oscar Rueda

(he/him/his)
Principal investigator

MRC Biostatistics Unit

About Professor Oscar Rueda

I am a Group Leader at the MRC Biostatistics Unit, and a CRUK Career Establishment Awardee. 

I am interested in the development of statistical models for the analysis of large genomic and transcriptomic datasets. Specifically, my goal is to integrate large breast cancer datasets in order to identify biomarkers that can be used to stratify patients and to identify potential drug candidates for specific subtypes. These biomarkers can be integrated in prognostic models that can be used to highlight patients at risk of relapse and to monitor patients while on treatment. The combination of clinical samples and preclinical models can accelerate the clinical implementation of new drugs, however there are multiple statistical challenges that need to be solved in order to bridge the gap between what we observe in vitro, in animal models and in the patient. They employ classical statistical models together with more recent machine learning approaches.

I have a PhD in Mathematics (Statistics) from the University of Valladolid, Spain. I have previously been in the Spanish National Cancer Centre (CNIO) and in CRUK as a postdoc.

Publications

Showing 1 to 10 of 102 publications

Other

Figure 6 from Modeling Drug Responses and Evolutionary Dynamics Using Patient-Derived Xenografts Reveals Precision Medicine Strategies for Triple-Negative Breast Cancer

Authors: A Shea, Y Eyal-Lubling, D Guerrero-Romero, R Manzano Garcia, W Greenwood, M O’Reilly, D Georgopoulou, M Callari, G Lerda, S Wix, A Giovannetti, R Masina, E Esmaeilishirazifard, W Cope, AG Martin, A Nagano, L Young, S Kupczak, Y Cheng, H Bardwell, E Provenzano, J Kane, J Lay, L Grybowicz, K McAdam, C Caldas, J Abraham, OM Rueda, A Bruna

Published:

DOI: 10.1158/0008-5472.28329134

Journal-article

The molecular cartography of malignant and benign sebaceous tumours.

Authors: I Ferreira, OM Rueda, L van der Weyden, S Sahni, O Cast, K Wong, M Del Castillo Velasco-Herrera, H Caldwell, JM Boccacino, T Alegbe, I Mehta, A Gunjur, P Gupta, V Harle, K Koga, I Matzusaki, M Fujimoto, K Wiedemeyer, A Stratigos, A Oniscu, K Wang, E Ruppin, P Demetter, IM Frayling, MJ Arends, T Brenn, DJ Adams

Published:

Journal: Nat Commun

DOI: 10.1038/s41467-025-66584-0