Professor Paul Kirk
(he/him/his)About Professor Paul Kirk
I am a Group Leader at the MRC Biostatistics Unit, in the Biostatistical Machine Learning theme.
Having previously made contributions to the field of statistical systems biology, my current research profile is at the intersection of precision medicine and statistical functional genomics. I am currently developing statistical and machine learning methods for the identification of clinically actionable disease subtypes.
I am also a member of the Cambridge Big Data Initiative and the CRUK Cambridge Centre.
Publications
Showing 1 to 10 of 87 publications
Annealed variational mixtures for disease subtyping and biomarker discovery.
Authors: E Prevot, R Toogood, F Pagani, PDW Kirk
Published:
Journal: Statistical Applications in Genetics and Molecular Biology
DOI: 10.1515/sagmb-2025-0001
Multi-stromal organoid co-cultures model pancreatic cancer and pancreatitis epithelial cell-fibroblast heterogeneity
Authors: W Li, M Jihad, EG Lloyd, G Mucciolo, JA Henríquez, M Zaccaria, PSW Cheng, S Harish, S Mills, PM Johnson, W Luo, AA Montero, A Deamer, R Brais, AM Piskorz, PDW Kirk, M Vallespinos, G Biffi
Published:
DOI: 10.64898/2025.12.05.692494
VICatMix: variational Bayesian clustering and variable selection for discrete biomedical data.
Authors: J Rao, PDW Kirk
Journal: Bioinform Adv
DOI: 10.1093/bioadv/vbaf055
Annealed variational mixtures for disease subtyping and biomarker discovery
Authors: E Prevot, R Toogood, F Pagani, PDW Kirk
Published:
Permutation invariant multi-output Gaussian Processes for drug combination prediction in cancer
Authors: L Rønneberg, V Lalchand, PDW Kirk
Published:
VICatMix: variational Bayesian clustering and variable selection for discrete biomedical data
Authors: J Rao, PDW Kirk
Published:
Effect on life expectancy of temporal sequence in a multimorbidity cluster of psychosis, diabetes, and congestive heart failure among 1·7 million individuals in Wales with 20-year follow-up: a retrospective cohort study using linked data.
Authors: RK Owen, J Lyons, A Akbari, B Guthrie, U Agrawal, DC Alexander, A Azcoaga-Lorenzo, AJ Brookes, S Denaxas, C Dezateux, AF Fagbamigbe, G Harper, PDW Kirk, EB Özyiğit, S Richardson, S Staniszewska, C McCowan, RA Lyons, KR Abrams
Journal: Lancet Public Health
DOI: 10.1016/S2468-2667(23)00098-1
Dose-response prediction for in-vitro drug combination datasets: a probabilistic approach.
Authors: L Rønneberg, PDW Kirk, M Zucknick
Published:
Journal: BMC Bioinformatics
DOI: 10.1186/s12859-023-05256-6
Bayesian outcome-guided multi-view mixture models with applications in molecular precision medicine
Authors: PDW Kirk, F Pagani, S Richardson
Published:
Clustering long-term health conditions among 67728 people with multimorbidity using electronic health records in Scotland.
Authors: AF Fagbamigbe, U Agrawal, A Azcoaga-Lorenzo, B MacKerron, EB Özyiğit, DC Alexander, A Akbari, RK Owen, J Lyons, RA Lyons, S Denaxas, P Kirk, AC Miller, G Harper, C Dezateux, A Brookes, S Richardson, K Nirantharakumar, B Guthrie, L Hughes, UT Kadam, K Khunti, KR Abrams, C McCowan
Journal: PLoS One
DOI: 10.1371/journal.pone.0294666