Disruption of the Connectome in Glioblastomas

Summary

The invasive behaviour of glioblastomas (the commonest, most malignant primary brain tumour) means that local treatments won’t cure these tumours, and this diffuse invasion means that there is a disruption of normal cognitive structures. For this reason our patients die from their disease within a number of months, but this survival is impacted by deterioration in cognitive function.

Our previous work has demonstrated that these tumours cause a large disruption in the structural connectome.

Project aims

This PhD will use the methodology we have developed, to study the impact of connectomic disruption on cognitive outcomes, survival and surgical planning. The results of this PhD could alter how we plan treatment and how we counsel patients.

Contact details

Mr Stephen Price (sjp58@cam.ac.uk) –Neurosurgery  

Opportunities

This opportunity is open to PhD applicants.