Investigating the use of AI-based Methods to Optimise the

Summary

There is increasing interest in the development of RNA-targeting therapies for the treatment of rare and complex neurogenetic disorders. However, the field is hampered by a lack of understanding of how to efficiently generate effective, cell type-specific therapies which minimise side effects.

Project aims

The aims of this project are:

To study the use of long- and short-read RNA-sequencing data to improve the design of RNA-targeting therapies with a focus on ASOs in human brain
To generate a “learning” data set using targeted long-read RNA-sequencing data on mono- and co-cultures.
To expand from the test data set to model cell type-specific ASO effects and generate a tool for ASO design.

Contact details

Professor Mina Ryten - mr2022@medschl.cam.ac.uk

Opportunities

This project is open to applicants who want to do a:

School of Clinical Medicine | University of Cambridge

Study