
MRC Mitochondrial Biology Unit
Our mission is to understand mitochondrial biology in health and disease and exploit this understanding to develop new therapies and improve human health.
We aim to understand the fundamental biochemical and biological processes taking place in mitochondria, and the roles and integration of mitochondria within the cell. We learn about the involvement of mitochondria and mitochondrial dysfunction in human diseases, and use our understanding and knowledge to develop new therapies to treat them.
We have 11 Principal Investigators who lead independent research groups. We have cross-disciplinary interactions between our groups, who also collaborate with other leading research groups on the local, national and international stage.
We have laboratories equipped with state-of-the-art instrumentation, with access to further large-scale facilities. We work closely with the Cambridge Institute for Medical Research (CIMR) clinical and non-clinical scientists, and with other clinical scientists in the School of Clinical Medicine.
We are supported by core funding from the Medical Research Council and closely integrated into the academic community of the University of Cambridge.
We are committed to mentoring and supervising our students to the highest possible standards and their success is very important to us. Our students organise an active social and academic calendar, including joint events with student societies in other Cambridge departments and institutes.
Public engagement
Our public engagement activities include:
- visits to local schools and other organisations
- participation in science festivals
- organisation of annual Open Days
- involvement in other events for public understanding of science
- engagement with artists and designers on the artistic interpretation of our science
You can find us on:
Our research themes
- Judy Hirst - Mitochondrial complex I: An intricate energy-converting machine, a cornerstone of mitochondrial metabolism, and a locus of mitochondrial dysfunction and disease
- Patrick Chinnery - Mitochondrial Genomics: Inherited and acquired variants of nuclear and mitochondrial DNA in human health and disease
- Edmund Kunji - Mitochondrial transport proteins: Highly dynamic integral membrane proteins required for the translocation of metabolites and cofactors, key to the function of the mitochondrion
- Michal Minczuk - Mitochondrial genetics: Mitochondrial genome engineering to unravel the genetic links between mitochondrial gene regulation and human disease for future therapies
- Michael Murphy - Mitochondrial ROS production: Central to many pathologies and signalling processes and a key target for novel therapies
- Kasparas Petkevicius - Mitochondrial phospholipids: Understanding the regulation and the biological importance of mitochondrial phospholipid composition
- Julien Prudent - Mitochondrial cell biology: Mitochondrial dynamics and membrane contact sites as key regulators of cell fate decisions
- Dylan Ryan - Mitochondrial metabolism: Metabolic reprogramming and metabolite signalling as regulators of inflammatory disease
- Jelle van den Ameele - Mitochondria in development: Neural stem cell-niche interactions that protect the developing and aging brain against mitochondrial dysfunction
- John Walker - Mitochondrial ATP synthase: cellular power generator, determinant of mitochondrial cristae formation, a site linked to human diseases
- Alex Whitworth - Mitochondria in neurodegeneration: Investigating the role of mitochondria and metabolism in the cause and therapeutic targeting of neurodegenerative diseases
Get in touch
Visit us or contact us

Visit us
MRC Mitochondrial Biology Unit
The Keith Peters Building
University of Cambridge
Cambridge Biomedical Campus
Hills Road
Cambridge
CB2 0XY
Tel: +44 1223 252700