Molecular mechanisms of microglia-driven neurodegeneration in human tauopathies
Summary
Neuroinflammation is associated with many neurodegenerative disorders. In experimental animals of tauopathies, microglia were shown to play a role in tau propagation and synapse loss, however the molecular and cellular processes driving tau accumulation and neurodegeneration in the context of human disease remain poorly understood.
We are investigating the role of microglial responses in human tauopathies with progressive supranuclear palsy (PSP) as the demonstrator condition.
Project aims
Using advanced spatial omics and high-resolution imaging techniques we will characterise the molecular signatures of microglia and relationship to neurodegenerative processes. This project relies on the large collection of well-characterised PSP brains in the Cambridge Brain Bank.
The candidate is interested in learning histology, imaging and analysis of multidimensional data. We anticipate to better understand the role of microglia in PSP and tauopathies, and hence, to guide the design of novel neuroimmune therapies and new disease biomarkers.
Contact details
Dr Annelies Quaegebeur - aq244@cam.ac.uk
Opportunities
This project is open to applicants who want to do a:
- PhD