Dr Nazima Pathan

Available for consultancy and editorial work. 

Accepting PhD Student Applications. 

Dr Nazima Pathan is an Associate Professor in Paediatric Intensive Care at the University of Cambridge, and is also Honorary Consultant at Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital.  

Her clinical practice and research are focused on improving care for critically ill children, particularly through her work on inflammation, sepsis, nutrition, and the complex relationships between the host and microbiome in critical illness. 

At the University of Cambridge, Dr Pathan is active in supporting undergraduate and postgraduate research, including education, mentoring and supervision.  

Research interests

Her research explores how immune responses and changes in the gut and lung microbiome affect severity of organ failure and recovery in critical illness. 

Her group is also interested in rapid diagnosis of infection in order to improve management of severe infection and rationalisation of antibiotics during critical illness.  

She led the Infection Control in Paediatric Intensive Care feasibility study to examine the role of selective digestive tract decontamination as an infection control strategy in the PICU setting.  

Her group played a role in enhancing our understanding of paediatric inflammatory multisystem syndrome associated with SARS-CoV-2 (PIMS-TS), focusing on its underlying mechanisms and improving treatment approaches.  

Dr Pathan collaborates widely with national and international teams aiming to advance paediatric critical care. Her work includes basic science research approaches in immunology, microbiology and complex datasets, alongside more translational research. 

Selected publications

Status of cerebrovascular autoregulation relates to outcome in severe paediatric head injury: STARSHIP, a prospective multicentre validation study 
S Agrawal, C Smith, SY Bogli, MM Placek, M Cabeleira, D White 
eClinicalMedicine 81

Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised...
IRL Kean, JA Clark, Z Zhang, E Daubney, D White, P Ferrando-Vivas
Gut 73 (6), 910-921

Enhanced CD95 and interleukin 18 signalling accompany T cell receptor Vβ21. 3+ activation in multi-inflammatory syndrome in children
Z Zhang, IRL Kean, LM Dratva, JA Clark, E Syrimi, N Khan, E Daubney
Nature Communications 15 (1), 4227

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study
LJ Schlapbach, D Ganesamoorthy, C Wilson, S Raman, S George
The Lancet Child & Adolescent Health 8 (5), 325-338

Enhanced diagnosis of severe bacterial and fungal respiratory infection in children using a rapid syndromic array—case report
JA Clark, T Gouliouris, AC Morris, MD Curran, D White, E Daubney
Translational Pediatrics 13 (4), 697