Professor Stefan Marciniak

I studied medicine at the University of Cambridge as part of its MB/PhD Programme. After medical posts in Cambridge, London and Edinburgh, I undertook post-doctoral training in New York funded by the Wellcome Trust and as an MRC Clinician Scientist Fellow back in Cambridge. I established my own group in CIMR as an MRC Senior Clinical Research Fellow in 2012.  I am now Professor of Respiratory Science at the University of Cambridge and an Honorary Consultant Respiratory Physician at Addenbrooke’s and Royal Papworth Hospitals. My laboratory research focuses on the role of stress signalling in lung disease.  My clinical research focuses on pleural medicine, especially the genetics of pneumothorax. I am Director of the University of Cambridge MB/PhD Programme.

Project/study information 

Proteins must be folded properly to function. If this becomes defective, cells experience stress and respond by clearing away these misfolded proteins for destruction. We are investigating how the response to this form of cellular stress is important in lung health and disease. Current projects in our group address a variety of lung diseases including: altered endoplasmic reticulum function in alpha1-antitrypsin deficiency; multiomics analysis of new models of mesothelioma; and the role of GCN2 signalling in pulmonary hypertension. 

Proteins must be folded properly to function. If this becomes defective, cells experience stress and respond by clearing away these misfolded proteins for destruction. We are investigating how the response to this form of cellular stress is important in lung health and disease. Current projects in our group address a variety of lung diseases including: altered endoplasmic reticulum function in alpha1-antitrypsin deficiency; multiomics analysis of new models of mesothelioma; and the role of GCN2 signalling in pulmonary hypertension.