Clinical Neurosciences projects
If you are interested in working on one of our clinical Neuroscience projects you should:
- browse the projects (listed by principal investigator)
- pick one that is in your area of interest
- contact the Principal Investigator to discuss a potential application
For general enquiries regarding Clinical Neurosciences postgraduate admissions, please email pgneurosci@medschl.cam.ac.uk
Learn more about the postgraduate application process.
Current projects
Professor Franklin Aigbirhio - Molecular Imaging Chemistry Laboratory
Edward Avezov - UK Dementia Research Institute
- Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology
- Exploration of Cellular Ultrastructure in Ageing and Alzheimer's Disease
- Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
- Monitoring Protein Aggregation and Aggregates’ Handling by Neurons
Michael Coleman - Clinical Neurosciences
- Probing the mechanism of programmed axon death using protein design
- The Roles of Programmed Axon Death in Human Disease
Professor Rita Horvath - Neurology
- Identifying Novel Genes and Developing Treatments for Children with Inherited Neuromuscular Diseases
- Mitochondrial Diseases and Immunity
- Trial Readiness in Ataxia Telangiectasia (AT)
- Unlocking mt-tRNA Synthetases: Impact on Neurodegeneration
Dr Maura Malpetti - Neurology
- Fluid biomarkers of Inflammation in Frontotemporal Dementia
- PET imaging for Inflammation in Frontotemporal Dementia and Progressive Supranuclear Palsy
Dr Luca Peruzzotti Jametti - Neurology
- Developing advanced human stem cell models to recapitulate neuron-glia interactions in chronic CNS inflammation
- Investigating cellular metabolism and inter-organelle dynamics in glial cells
- Unravelling the metabolic basis of aberrant neuroimmune interactions in MS-Associated cognitive decline
Professor Stefano Pluchino - Neurology
- A Cell Interactome Approach to Model, Characterise and understand Novel Mechanisms of Disease in Progressive Multiple Sclerosis
- Epigenetic drivers of Glial Toxicity in Progressive Multiple Sclerosis (P-MS)
- Metabolic Determinants of Astrocyte – Microglial Interactions in Smoldering Brain Disease
- The role of Retrograde Mitochondrial Signalling and Epigenetic Reprogramming in Glial Toxicity and Neuroinflammation in Progressive Multiple Sclerosis
Professor Chris Rodgers - WBIC
Professor Mina Ryten - UK Dementia Research
- Investigating Novel Transcription of the X Chromosome and its role in Developmental Disorders of the Human Brain
- Investigating the role of cell-type specific errors in RNA processing in Parkinson’s Disease
- Investigating the use of AI-based Methods to Optimise the Development of RNA-Targeting Therapies
Dr Selena Milicevic Sephton - WBIC
Dr Peter Smielewski - Cambridge Neuroscience
- Continuous monitoring of cerebral blood flow autoregulation in traumatic brain injury patients
- Development of a ‘Digital-Twin’ model for cerebrospinal fluid dynamics to use in real-time monitoring of patients after severe traumatic brain injury
- Development of New, Robust, Approaches for Continuous Monitoring of Vascular and Brain Tissue Physical Properties in Traumatic Brain Injury Patients
- Enhancing diagnostic capability of CSF dynamics in normal pressure hydrocephalus through advanced analysis of intracranial pressure waveforms and PC MRI Images
- Machine Learning Supported Application of Advanced Neuromonitoring for Individualised Guided Management of Acute Traumatic Brain Injury in Intensive Care
Dr Jelle van den Ameele - Neurology and Mitochondrial Biology Unit
- mRNA-LNP-based gene therapy for Mitochondrial DNA maintenance disorders
- Neural Stem Cell – Niche Interactions in Mitochondrial Disease
- Single-cell CRISPR Screening for Nuclear Modulators of Mitochondrial Dysfunction