Clinical Neurosciences projects
If you are interested in working on one of our clinical Neuroscience projects you should:
- browse the projects (listed by principal investigator)
- pick one that is in your area of interest
- contact the Principal Investigator to discuss a potential application
For general enquiries regarding Clinical Neurosciences postgraduate admissions, please email pgneurosci@medschl.cam.ac.uk
Learn more about the postgraduate application process.
Current projects
Professor Franklin Aigbirhio - Molecular Imaging Chemistry Laboratory
Edward Avezov - UK Dementia Research Institute
- Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology
- Exploration of Cellular Ultrastructure in Ageing and Alzheimer's Disease
- Gaining Control of Intracellular Stages for Amyloidogenesis via High-Resolution Optical Biosensing Approaches coupled to Nanobody-Based Protein Localisation Control
- Monitoring Protein Aggregation and Aggregates’ Handling by Neurons
Dr Will Brown – Neurology
- Preventing Multiple Sclerosis: AI-Driven Identification of Modifiable Exposures - A Population-Scale Analysis Using OpenSAFELY and Target-Trial Emulation
- Using Real-World Data and Target-Trial Emulation to Evaluate Disease-Modifying Therapies in Multiple Sclerosis: Focus on Biosimilars
Michael Coleman - Clinical Neurosciences
Professor Rita Horvath - Neurology
- Identifying Novel Genes and Developing Treatments for Children with Inherited Neuromuscular Diseases
- Mitochondrial Diseases and Immunity
- Trial Readiness in Ataxia Telangiectasia (AT)
- Unlocking mt-tRNA Synthetases: Impact on Neurodegeneration
- Investigating Pathogenic Mechanisms and Therapeutic Approaches for MTDNA Mutations in Cellular Models and Patients
Professor Joanne Jones – Clinical Neurosciences
Dr Maura Malpetti - Neurology
- Fluid biomarkers of Inflammation in Frontotemporal Dementia
- PET imaging for Inflammation in Frontotemporal Dementia and Progressive Supranuclear Palsy
Dr Luca Peruzzotti Jametti - Neurology
- Developing advanced human stem cell models to recapitulate neuron-glia interactions in chronic CNS inflammation
- Investigating cellular metabolism and inter-organelle dynamics in glial cells
- Unravelling the metabolic basis of aberrant neuroimmune interactions in MS-Associated cognitive decline
Professor Stefano Pluchino - Neurology
- A Cell Interactome Approach to Model, Characterise and understand Novel Mechanisms of Disease in Progressive Multiple Sclerosis
- Epigenetic drivers of Glial Toxicity in Progressive Multiple Sclerosis (P-MS)
- Metabolic Determinants of Astrocyte – Microglial Interactions in Smoldering Brain Disease
- The role of Retrograde Mitochondrial Signalling and Epigenetic Reprogramming in Glial Toxicity and Neuroinflammation in Progressive Multiple Sclerosis
Dr Elizabeth Radford – Clinical Neurosciences
- Accelerating the Diagnosis and Treatment of Genetic Conditions by Empirically Interrogating Splice Variants at Scale
- Accelerating the Diagnosis and Treatment of Genetic Conditions by Mapping and Manipulating Promoter Variation at Scale
Professor Chris Rodgers - WBIC
- Ultra-High Field (7T and 11.7T) Magnetic Resonance Imaging (MRI) Development
- Applying Parallel-Transmit 7T MRI (pTx-7T-MRI) to enable Sub-Millimetre Imaging with consistent contrast across the whole Brain
- Imaging Brain Energy Metabolism Non-Invasively
Professor Mina Ryten - UK Dementia Research
- Cell-type specific RNA processing defects in neurodegeneration
- Developing RNA-targeted therapeutic strategies for rare neurological disease
- Investigating Novel Transcription of the X Chromosome and its role in Developmental Disorders of the Human Brain
- Investigating the role of cell-type specific errors in RNA processing in Parkinson’s Disease
- Investigating the use of AI-based Methods to Optimise the Development of RNA-Targeting Therapies
Dr Selena Milicevic Sephton - WBIC
- Development of PET Radiotracers for Neurodegeneration
- Development of PET Radiotracers for Neuroinflammation
Dr Peter Smielewski - Cambridge Neuroscience
- Continuous monitoring of Cerebral blood flow Autoregulation and Derived Individualised Pressure Management Targets in Traumatic Brain Injury Patients
- From Monitoring to Personalised Treatment Targets in Paediatric Traumatic Brain Injury
- Development of a ‘Digital-Twin’ model for cerebrospinal fluid dynamics to use in real-time monitoring of patients after severe traumatic brain injury
- Machine Learning Supported Application of Advanced Neuromonitoring for Individualised Guided Management of Acute Traumatic Brain Injury in Intensive Care
Dr Jelle van den Ameele - Neurology and Mitochondrial Biology Unit
- mRNA-LNP-based gene therapy for Mitochondrial DNA maintenance disorders
- Neural Stem Cell – Niche Interactions in Mitochondrial Disease
- Single-cell CRISPR Screening for Nuclear Modulators of Mitochondrial Dysfunction
Professor Patrick Yu-Wai-Man - Neuro-Ophthalmology and Genetics
Dr Smriti Agarwal
Dr William McEwan
Professor Hugh Markus
- Biomarkers for Cerebral Small Vessel Disease and Vascular Cognitive Impairment
- Unravelling the mechanisms of Vascular Dementia
Dr Alessandra Granata
Professor Emmanuel Stamatakis
Dr Tim Rittman
Professor Stephen Sawcer
- Mitochondrial Genetic Determinants of Multiple Sclerosis
- Establishing the Determinants of CNS Resilience
- Structural Genetic variation in Multiple Sclerosis
Dr András Lakatos
- Preclinical Human Neural Organoid and Computational/AI Model Development
- Regeneration Failure and Repair in Human Neural Injuries and Neurodegeneration: The role of Astroglial Cells
- Novel Strategies for Discovering Human aspects of early ALS/MND Pathogenesis with a view to Clinical Translation
Professor Adel Helmy
- Neuroinflammatory Mediators in the Pathophysiology of Traumatic Brain Injury
- Metabolic Derangements following Traumatic Brain Injury
Dr Annelies Quaegebeur
- Molecular Mechanisms of Microglia-Driven Neurodegeneration
- Understanding how co-pathologies drive Dementia
Dr Kamen Tsvetanov
- Brain Resilience in Healthy Ageing and Dementia
- Multimodal Imaging of Neurodegeneration and Brain Resilience
- Vascular Contributions to Cognitive Ageing and Dementia
- Improving Functional Neuroimaging for Ageing and Dementia Research
- AI for Neuroimaging of Ageing and Dementia
- Understanding Brain Resilience, Vascular Health and Early Neurodegeneration